陈竺的研究小组用现代科学的方法发现中医处方各种成份联合启动"君臣佐使"四种过程，它们各司其职协同作用（附录三）。
中医处方的最终目的是达到某种功能的阴平阳秘，也就是功能内稳态（function-specific homeostasis, FSH）（附录一）。中药处方的"君臣佐使"四种过程都是为了康复FSH。
运动员的项目内稳态（sport-specific homeostasis, SSH）属于FSH。教练可以用类君臣佐使"四种办法来训练运动员。
可以用"君臣佐使"的方法将建立SSH所需要的功能或过程进行分类。目前，我们将这些系统分为建立SSH所必需的系统（SSH-essential system, SES）和非必需的系统（SSH-non-essential system, SNS）。用"君臣佐使"的方法可以将这些系统的过程分为SSH特异的君过程（SSH-specific emperor process, SSEP）、臣过程（SSH-specific minister process, SSMP）、佐过程（SSH-specific assistant process, SSAP）和使过程（SSH-specific delivering servant process, SSDP）。SES包括SSH必需的骨骼肌子系统和神经子系统，相应的骨骼肌功能包括骨骼肌收缩、供能和神经肌肉传递等应该属于SSEP，氧化抗氧化过程应该属于SSAP，对建立SSH的兴趣等精神心理系统的过程应该属于SSDP，其它过程应该属于SSMP。
在中药中，SSDP属于药引子，所谓万事俱备只欠东风。按照Noakes等人提出的运动性疲劳的中枢模型（附录二）正好说明这一点。
附录一 [原创] Life after death：内稳态转换
http://bbs.tiyuol.com/thread-5239-1-1.html
附录二 徐晓阳 刘承宜 刘晓光 邓树勋. 运动性疲劳的新观点：从突变到神经调控. 体育网刊. (2):
http://www.chinatyxk.com/gb/tywk ... sid=7&bookid=63
附录三 Traditional Chinese medicine: Ancient formula in modern times
http://www.nature.com/nchina/2008/080326/full/nchina.2008.64.html
Traditional Chinese medicine (TCM) follows the tenet that a formula should have four major ingredients, each playing its unique role while working together synergistically, to achieve the optimum therapy. The four major ingredients have been described in ancient texts as 'emperor', 'minister', 'assistant' and 'delivering servant'. However, the molecular basis of such combination therapy has never been explained convincingly at the biochemical level for any known TCM formula. Zhu Chen and Saijuan Chen at Shanghai Jiao Tong University and co-workers1 have taken one well-known and clinically tested TCM formula for leukaemia therapy as a model and unveiled the biochemical roles of each ingredient.
The formula, known as realgar–Indigo naturalis formula (RIF), contains realgar and indigo minerals, as well as the herb red sage root. Through molecular analyses, the researchers showed that arsenic in realgar works as 'emperor' by directly attacking the receptor oncoprotein in leukaemia cells. Indirubin, the active ingredient in indigo, works as 'assistant' by antagonizing the toxicity of arsenic and slowing leukaemia cell growth. Tanshinone, the active ingredient in red sage root, acts as 'minister' by partially restoring those pathways that stop leukaemia spreading. Lastly, indurbin and tanshinone work as 'delivering servants'; these ingredients can enhance the cellular uptake of arsenic by increasing the gene-expression level and therefore the synthesis of carrier pore proteins in the cell membrane.
The study explains the molecular modes and synergistic effects of principal ingredients in a clinically proven TCM formula. This finding will help bridge the gap between TCM and modern medical sciences.
The authors of this work are from:
State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Shanghai Center for Systems Biomedicine, School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China; Department of Biostatistics, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Reference
Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yan XJ, Xu F, Wang BS, Mao JH, Shen ZX, Chen SJ, Chen Z. 2008. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4826-31.
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本帖最后由 刘承宜 于 2008-4-2 07:17 AM 编辑 ]
