本人（Timon Cheng-Yi Liu）再次推荐如下论文为年度华人论文，请网友投票支持我：
http://spotlight.nature.com/nchina/paper/278
Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao L. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A. 2008 Feb 12;105Devil:2117-22.
Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (microbiome) and individual variations in the microbiome influence host health, may be implicated in disease etiology, and affect drug metabolism, toxicity, and efficacy. However, the molecular basis of these microbe-host interactions and the roles of individual bacterial species are obscure. We now demonstrate a"transgenomic" approach to link gut microbiome and metabolic phenotype (metabotype) variation. We have used a combination of spectroscopic, microbiomic, and multivariate statistical tools to analyze fecal and urinary samples from seven Chinese individuals (sampled twice) and to model the microbial-host metabolic connectivities. At the species level, we found structural differences in the Chinese family gut microbiomes and those reported for American volunteers, which is consistent with population microbial cometabolic differences reported in epidemiological studies. We also introduce the concept of functional metagenomics, defined as "the characterization of key functional members of the microbiome that most influence host metabolism and hence health." For example, Faecalibacterium prausnitzii population variation is associated with modulation of eight urinary metabolites of diverse structure, indicating that this species is a highly functionally active member of the microbiome, influencing numerous host pathways. Other species were identified showing different and varied metabolic interactions. Our approach for understanding the dynamic basis of host-microbiome symbiosis provides a foundation for the development of functional metagenomics as a probe of systemic effects of drugs and diet that are of relevance to personal and public health care solutions.
（该论文网络版于2008年2月5日在PNAS网站发表，题目是“共生微生物可以改变
人体的代谢表型”，该研究是中英两国的5个研究机构多学科合作的结果。5个通讯作者：
中科院武汉物理与数学研究所的唐惠儒教授，国家人类基因组南方中心赵国屏院士，英国
帝国理工Jeremy Nicholson教授，浙江大学第一附属医院李兰娟院士，上海交通大学系统
生物医学研究院赵立平教授。赵教授为该项目的协调人和论文的提交作者）
更详细的介绍参加如下帖子
[建议] 《自然中国》年度华人论文评选: 陈竺院士推荐的系统生物学最新力作
http://bbs.tiyuol.com/thread-4694-1-1.html
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本帖最后由 刘承宜 于 2008-2-22 11:38 PM 编辑 ]
